Description

COMBIHALE 0.5MG Injection: A Comprehensive Overview
Introduction
COMBIHALE 0.5MG Injection is a combination medication primarily used for the treatment of respiratory conditions such as asthma and Chronic Obstructive Pulmonary Disease (COPD). This medication combines two active ingredients: Ipratropium Bromide and Salbutamol Sulfate, which work synergistically to provide effective relief from bronchospasm and improve breathing.
Composition and Mechanism of Action
Each 2.5mL respule of COMBIHALE contains:
0.5mg Ipratropium Bromide
2.5mg Salbutamol Sulfate
Ipratropium Bromide is an anticholinergic agent that helps to relax the muscles around the airways, preventing them from narrowingSalbutamol Sulfate is a beta-2 agonist that works by stimulating beta-2 receptors in the lungs, leading to the relaxation of bronchial muscles and opening up the airways¹.
Indications
COMBIHALE 0.5MG Injection is indicated for:
Treatment of bronchospasm associated with COPD and asthma
Rapid relief of symptoms such as wheezing, shortness of breath, and chest tightness¹
Dosage and Administration
COMBIHALE is intended for nebulization only. The dosage varies based on the severity of the condition and the patient’s age:
Adults and Adolescents (≥12 years): 1 respule every 6 to 8 hours as needed for bronchospasm. For acute severe asthma, 1 respule every 20 minutes for up to 3 doses, then as needed for up to 3 hours¹.
Children (<12 years): There is limited experience with using this medication in children under 12 years¹.
Contraindications
COMBIHALE should not be used in patients with:
Hypersensitivity to Ipratropium Bromide, Salbutamol, or any other components of the formulation
Hypertrophic obstructive cardiomyopathy
Tachyarrhythmia¹
Side Effects
Common side effects include:
Upper respiratory tract infection
Nasopharyngitis
Cough
Bronchitis
Headache
Dyspnea¹
Precautions
Patients should use COMBIHALE with caution if they have:
Cardiovascular disorders
Narrow-angle glaucoma
Prostate problems or difficulty passing urine¹
Conclusion
COMBIHALE 0.5MG Injection is a potent combination therapy offering significant relief for patients suffering from respiratory conditions like asthma and COPD. Its dual-action mechanism ensures greater bronchodilation, making it an effective option for managing bronchospasm and improving overall respiratory function.